Tendonitis, Tendon Degeneration, and Pain. You may want to be aware of the Side Effects of Cipro if you have been or are considering taking the Ciprofloxacin antibiotic for any reason. Levaquin Tendonitis are BAD News… Cipro Tendonitis and Levaquin Tendonitis are BAD news for you if you have or are currently taking either of these drugs that have the potential to cause serious irreversible disabling damage. Like other fluoroquinolone drugs, Cipro causes side effects on tendon like tendonitis and causes tendon rupture. A tendon attaches a muscle to a bone to make movement of joints possible. Tendinopathy induced by fluoroquinolone (FQ) antibiotics is a topic of controversy, with many researchers believing in a direct causal relationship while others believing that the risk is negligible. Side effects of Cipro can be mild or serious and people using this drug experience side effects differently. Always discuss with your doctor about side effects because he or she knows your medical history, how your body may react to treatment with Cipro and the possible side effects that you may experience. Common side effects of Cipro include: There's a possibility that you had a severe reaction to Cipro which belongs to the class of antibiotic drugs that, unfortunately, has the most side-effects of all. Along with its needed effects, ciprofloxacin (the active ingredient contained in Cipro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Fluoroquinolones like Cipro and Levaquin can cause tendon rupture. The fact that he only took one, makes me say that he should never take them again. In fact, the FDA even has a Black Box Warning, the strongest warning possible for a drug, about the risk of tendon rupture with these drugs, and one study claims, “Tendinopathy are classic side effects observed with fluoroquinolones antibiotics” 1. July 8, 2008 -- Federal regulators are ordering new warnings on Cipro and similar antibiotics because of increased risk of tendinitis and tendon rupture.